Global Oncology is a growing sub-speciality, with the potential for bidirectional learning to improve patient outcomes in both high and low and middle-income countries (LMICs). Determining how best to prioritize limited resources for cancer in LMICs is essential. Resource stratified guidelines have been developed to provide LMICs with a hierarchy of treatment recommendations depending on resource availability. In this talk, we will review existing resource stratified guidelines for cancer care, and examine how well recommendations for chemotherapy, endocrine therapy and targeted treatments agree across organizations. We will discuss whether these guidelines can be used to cancer inform policy decisions in LMICs. We will then examine the global treatment needs and costs for chemotherapy, endocrine therapy and targeted treatments for breast cancer if all patients are treated according to the National Comprehensive Cancer Network (NCCN) resource stratified guidelines. Finally, we will discuss the importance of interactive models that allow hospitals, regions and countries to use their own population level data and costs to generate accurate predictions of cancer treatment needs, which can in turn inform policy decisions and planning for cancer care.